Appendix G Examples of Potential Needs and Uses for Biospecimens by Constituency User Type Needs Uses Academic Researchers 20-100 samples or more per experiment < 100 mg to 100-200mg Standard clinical quality RNA grade Protein grade Biology (genetic basis of human disease) Aberrations of signal transduction Genomic analysis, i.e., mutation screening, loss-ofheterzygosity studies, etc. Pharmaceutical Companies 20-100 samples per experiment Multiple experiments (~ 1,000 samples per year) < 100 mg to 100-200 mg Standard clinical quality RNA grade Protein grade Drug and diagnostics development Target credentialing and validation Biotechnology Companies 20-100 samples per experiment Multiple experiments (~ 1,000 samples per year) < 100 mg to 100-200 mg Standard clinical quality RNA grade Protein grade Biomarker discovery and validation Target identification

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